Serum soluble-fms-like tyrosine kinase 1-to-placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy
The soluble fms-like tyrosine kinase 1-to-placental growth factor ratio of >38 measured on the Elecsys platform predicted the development of preeclampsia with severe features, delivery, and adverse maternal and fetal/neonatal outcomes within 2 weeks of testing among preterm pregnant women hospitalized with a hypertensive disorder of pregnancy.
Authors
- Deepjot Singh
- Yvonne Gollin
- Judette Louis (ORCID: https://orcid.org/0000-0002-1336-7886)
- Maged M. Costantine (ORCID: https://orcid.org/0000-0003-4076-469X)
- Kim Boggess
- Martin Hund (ORCID: https://orcid.org/0000-0002-4756-4503)
- Britta Panda
- Anders Hayden Berg (ORCID: https://orcid.org/0000-0002-5736-0686)
- S. Ananth Karumanchi (ORCID: https://orcid.org/0000-0002-2281-6831)
- Sarosh Rana (ORCID: https://orcid.org/0000-0002-5828-7433)
- Irina Burd (ORCID: https://orcid.org/0000-0001-7256-7784)
- Tiffany A. Moore Simas (ORCID: https://orcid.org/0000-0002-8356-6418)
- Danielle Durie
- Sarah J. Kilpatrick (ORCID: https://orcid.org/0000-0001-8322-3709)
- Ravi Thadhani (ORCID: https://orcid.org/0000-0001-8315-9938)
- Martha Bautista
- Vinícius F. Calsavara (ORCID: https://orcid.org/0000-0003-2332-5863)
- Elizabeth Lemoine (ORCID: https://orcid.org/0009-0006-1120-5492)
- Blair J. Wylie (ORCID: https://orcid.org/0000-0003-4818-1050)
- Robert M. Silver (ORCID: https://orcid.org/0000-0002-5794-3152)
- Beth A. Plunkett (ORCID: https://orcid.org/0000-0003-1712-2226)
- Rachel K. Scott (ORCID: https://orcid.org/0000-0002-1519-9222)
- Jimmy Espinoza (ORCID: https://orcid.org/0000-0002-9830-2212)
- Errol R. Norwitz (ORCID: https://orcid.org/0000-0003-4643-1546)
- Amy Murtha (ORCID: https://orcid.org/0000-0003-4682-215X)
- Samantha Wiegand
- Stephanie L. Gaw (ORCID: https://orcid.org/0000-0003-0891-6964)
- Guo Ge (ORCID: https://orcid.org/0000-0002-6362-772X)
Institutions
- University of North Carolina at Chapel Hill (US)
- Roche (Switzerland) (CH)
- University of Maryland, Baltimore (US)
- Cedars-Sinai Medical Center (US)
- Tufts Medical Center (US)
- Roche (United States) (US)
- UMass Memorial Health Care (US)
- Lehigh Valley Hospital-Pocono (US)
- Beth Israel Deaconess Medical Center (US)
- Torrance Memorial Medical Center (US)
- Emory Healthcare (US)
- NorthShore University HealthSystem (US)
- Emory University (US)
- University of California, San Francisco (US)
- University of Utah (US)
- University of South Florida (US)
- Newton Wellesley Hospital (US)
- Johnson University (US)
- Miami Valley Hospital (US)
- The Ohio State University Wexner Medical Center (US)
- University of Chicago Medical Center (US)
- Memorial Medical Center (US)
- Lehigh Valley Health Network (US)
- Sharp Mary Birch Hospital for Women & Newborns (US)
- UMass Memorial Medical Center (US)
- Wake Forest University (US)
- Columbia University (US)
- MedStar Health (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- American Journal of Obstetrics and Gynecology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.ajog.2025.11.006
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00