Modulatory Effects of Jujuboside A on Amino Acid Neurotransmitter Profiles in Tic Disorder
JuA can improve stereotypical behaviors in TD rats by regulating the levels of Glu and GABA in the CPu extracellular fluid, possibly through the upregulation of GLT-1 and GLAST protein expression. The combination of JuA and Tiapride offers enhanced therapeutic effects, providing a new approach for the treatment of TD.
Authors
- Meiyu Zhang (ORCID: https://orcid.org/0000-0003-4634-6800)
- Fei Fan (ORCID: https://orcid.org/0000-0002-3831-2646)
- Si Zhang (ORCID: https://orcid.org/0000-0002-5682-4995)
- Fei Han (ORCID: https://orcid.org/0000-0002-8072-9701)
- Hongwei Wu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/brb3.71041
- Citations
- 1
- Primary Topic
- Ziziphus Jujuba Studies and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- China Academy of Chinese Medical Sciences