Exploring the pharmacokinetic interactions between cisplatin and Triphala through in-vitro, in-vivo, and in-silico approaches – A pilot study to bridge modern medicine with Ayurveda
The results suggest that Triphala may interact with cisplatin by inhibiting the CYP2E1 enzyme, potentially affecting the metabolism and toxicity of cisplatin. These findings highlight the need for further research to evaluate the clinical implications of using Triphala alongside cisplatin-based cancer therapies.
Authors
- Gouri Nair (ORCID: https://orcid.org/0000-0003-2081-6827)
- Taruna Kumari (ORCID: https://orcid.org/0000-0001-8151-8079)
- Kamatchi Sundara Saravanan
- Lakshmi Sundar (ORCID: https://orcid.org/0000-0002-8285-0097)
- G. N. S. Hemasree
- Ganesan Rajalekshmi Saraswathy
Institutions
- M S Ramaiah University of Applied Sciences (IN)
Publication Details
- Journal
- Journal of Ayurveda and Integrative Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jaim.2025.101253
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00