Multifocal Kaposiform Hemangioendothelioma Successfully Treated With Sirolimus Monotherapy
Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that typically presents in infancy and may be associated with the Kasabach-Merritt phenomenon (KMP). We present a challenging case of multifocal KHE on the leg of an infant, initially suspected at birth to be a reticulate port wine birthmark. Skin biopsy and imaging supported the rare diagnosis of multifocal KHE. Complicated by KMP, he was started on sirolimus monotherapy with significant improvement in his widespread disease.
Authors
- Matthew J. Mahoney (ORCID: https://orcid.org/0000-0002-9482-9607)
- Emily Greengard (ORCID: https://orcid.org/0000-0002-2963-5638)
- Daniel D. Miller (ORCID: https://orcid.org/0000-0002-4931-9528)
- Sheilagh Maguiness (ORCID: https://orcid.org/0000-0002-0033-8285)
- Bradley J. Segura
- Michael A. Murati (ORCID: https://orcid.org/0000-0002-2943-7084)
- John Leister
- Alex Hoover (ORCID: https://orcid.org/0000-0002-2368-296X)
- Erin P. Fritz
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-08-28
- DOI
- https://doi.org/10.17615/gte5-rg36
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00