Sex Differences and Androgen Regulation Shape Mucosal Immune Phenotype, Gut Microbiota, and Microbiota-Derived Lactate in SKG Arthritis Model
This study highlights the significant role of sex and androgen regulation in arthritis development, revealing complex interactions between hormones, microbiota, and immune regulation. These findings suggest new avenues for sex-specific therapeutic strategies and precision interventions targeting microbiota and metabolic modulation in arthritis and other autoimmune diseases.
Authors
- Xi Wu (ORCID: https://orcid.org/0009-0005-5842-6148)
- Yubin Cao (ORCID: https://orcid.org/0000-0001-8553-1430)
- Lingjuan Jiang (ORCID: https://orcid.org/0000-0001-5509-1585)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
- Wenjing Wang (ORCID: https://orcid.org/0000-0002-4527-1168)
- Peng Wang (ORCID: https://orcid.org/0000-0002-3350-1835)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/jir.s552491
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College