Association of CXCL16 in aseptic loosening following total hip arthroplasty and its effect on bone metabolism: a case-control study
Our findings reveal a significant association between elevated CXCL16 expression and an increased RANKL/OPG ratio in periprosthetic synovial tissues, suggesting a role for CXCL16 in promoting osteoclast differentiation and activity. These findings offer preliminary insights into CXCL16 as a biomarker and a potential therapeutic target for managing bone resorption in aseptic loosening.
Authors
- Yongjie Qiao
- Langfeng Zhu (ORCID: https://orcid.org/0000-0001-9738-479X)
- Shenghu Zhou (ORCID: https://orcid.org/0000-0002-8203-6546)
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Xiao-Yang Song
- Jiahuan Li (ORCID: https://orcid.org/0000-0002-0016-7682)
- Zhiqiang Lin (ORCID: https://orcid.org/0000-0002-4880-8899)
- Peijie Li (ORCID: https://orcid.org/0000-0003-1026-0925)
- Jiankang Zeng
Institutions
- Qingdao University (CN)
- People's Liberation Army 401 Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Beijing Anzhen Hospital (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1080/07853890.2025.2528976
- Citations
- 1
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 2.01