Vasostatin-2 attenuates injury-induced neointimal hyperplasia through the ACE2/MasR/PPARγ/NR1D1/Gas1 axis
Decreased serum vasostatin-2 levels are associated with coronary artery restenosis in patients with coronary angioplasty. Vasostatin-2 attenuates vascular injury-induced neointimal growth in mice and inhibits the proliferation of VSMCs in vitro through the ACE2/NR1D1/Gas1 pathway.
Authors
- Qiujing Chen (ORCID: https://orcid.org/0000-0002-5668-3774)
- Ying H. Shen (ORCID: https://orcid.org/0000-0003-4119-115X)
- Ruiyan Zhang (ORCID: https://orcid.org/0000-0002-6739-2075)
- Fenghua Ding (ORCID: https://orcid.org/0000-0001-9507-4704)
- Leying Li (ORCID: https://orcid.org/0000-0002-7877-620X)
- Weifeng Shen
- Raffaele De Caterina (ORCID: https://orcid.org/0000-0003-1637-574X)
- Lin Lu (ORCID: https://orcid.org/0000-0003-0145-8008)
- Xinrui Wu (ORCID: https://orcid.org/0000-0002-5160-538X)
- Shuai Chen (ORCID: https://orcid.org/0000-0002-6812-1525)
- Feifei Li (ORCID: https://orcid.org/0000-0003-2282-3019)
- Xiaoqun Wang (ORCID: https://orcid.org/0000-0003-3440-2617)
- Jingmeng Liu (ORCID: https://orcid.org/0000-0002-2218-9380)
- Rosalinda Madonna (ORCID: https://orcid.org/0000-0002-7877-0035)
- Yang Dai
- Yipaerguli Maimati
Institutions
- University of Pisa (IT)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/cvr/cvaf192
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00