Mitochondrial Ca <sup>2+</sup> overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure
Mitochondrial Ca<sup>2+</sup> overload significantly contributes to arrhythmias by disrupting respirasome function and increasing oxidative stress, impairing cellular Ca<sup>2+</sup> dynamics. Modulating mitochondrial Ca<sup>2+</sup> transport might be a promising strategy for developing innovative antiarrhythmic therapies.
Authors
- Felipe Salazar‐Ramírez (ORCID: https://orcid.org/0000-0001-5136-0063)
- Flavio F. Contreras‐Torres (ORCID: https://orcid.org/0000-0003-2375-131X)
- Luis Alberto Luévano‐Martínez (ORCID: https://orcid.org/0000-0003-2598-7967)
- Ana C. Murrieta (ORCID: https://orcid.org/0000-0002-7619-8880)
- Abraham Méndez‐Fernández (ORCID: https://orcid.org/0009-0009-8484-3382)
- Christian Silva‐Platas (ORCID: https://orcid.org/0000-0003-3760-8733)
- Ernesto A. Aiello (ORCID: https://orcid.org/0000-0002-8914-5067)
- Alfredo Cabrera‐Orefice (ORCID: https://orcid.org/0000-0002-2042-3794)
- Guillermo Torre‐Amione (ORCID: https://orcid.org/0000-0001-9950-0416)
- Judith Bernal‐Ramírez (ORCID: https://orcid.org/0000-0003-1223-7366)
- Gerardo García‐Rivas (ORCID: https://orcid.org/0000-0003-4731-3293)
- José Luis Velasco‐Bolom
- Carolina A. Morales‐Ochoa
- Gricelda Mendiola‐Garza
Institutions
- Goethe University Frankfurt (DE)
- Cornell University (US)
- Hospital Zambrano Hellion (MX)
- Methodist Hospital (US)
- Centro de Investigaciones Cardiovasculares (AR)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/bph.70253
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Instituto Tecnológico y de Estudios Superiores de Monterrey