Succinic acid-driven gut-fat axis orchestrates abdominal fat deposition in chickens via adipocyte-macrophage crosstalk
This study delineates a succinic acid-driven "gut-fat axis" governing abdominal fat deposition in broilers, integrating gut microbiota dysbiosis and macrophage-mediated inflammatory adipogenesis. By identifying succinic acid as a cross-organ signaling molecule that enhances lipid absorption and activates macrophage-dependent adipogenesis, we establish systemic metabolic-immune crosstalk as a pivotal regulatory mechanism. These findings redefine fat deposition as a process extending beyond adipose-centric models, advancing multi-omics-guided strategies for sustainable poultry production.
Authors
- Haoqi Peng
- Qinghua Nie (ORCID: https://orcid.org/0000-0003-3934-3820)
- Xiquan Zhang (ORCID: https://orcid.org/0000-0002-7940-1303)
- Chuang Hu (ORCID: https://orcid.org/0000-0002-9051-3242)
- Jiahui Chen (ORCID: https://orcid.org/0000-0002-0742-8697)
- Chen Geng-Hua (ORCID: https://orcid.org/0000-0001-7418-9537)
- Yu Wang (ORCID: https://orcid.org/0000-0001-8826-7911)
- Wen Luo (ORCID: https://orcid.org/0000-0002-3014-1846)
- Qi Lin (ORCID: https://orcid.org/0009-0005-0874-6469)
Institutions
- South China Agricultural University (CN)
- Ministère de l'Agriculture et de la Souveraineté alimentaire (FR)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s40104-025-01278-7
- Citations
- 1
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 1.19