Corynoline enhances sorafenib sensitivity in hepatocellular carcinoma via NOS3-mediated ROS production
This study first revealed that Cory acted synergistically with Sora to inhibit HCC growth through NOS3-mediated ROS production and IL-18 secretion, suggesting the potential of Cory as a sorafenib sensitizer.
Authors
- Shangjun Zhou
- Qiaoli Yi
- Xi Chen (ORCID: https://orcid.org/0000-0003-2675-695X)
- Jiayu Wang (ORCID: https://orcid.org/0000-0002-5608-0738)
- Yuanliang Yan (ORCID: https://orcid.org/0000-0001-6610-3617)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13020-025-01259-y
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00