RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway
These findings suggest that RRM2 plays a crucial protective role against diabetic renal injury by mitigating oxidative stress, apoptosis, and ferroptosis <i>via</i> PI3K/Akt activation. Serum RRM2 may serve as a novel biomarker for early DN detection, and therapeutic strategies targeting RRM2 may offer potential benefits in preventing diabetic kidney disease progression.
Authors
- Chang-Chun Gao
- Fenghua Ding (ORCID: https://orcid.org/0000-0001-9507-4704)
- Xia Jiang (ORCID: https://orcid.org/0000-0002-0981-6183)
Institutions
- Nantong University (CN)
- Second People's Hospital of NanTong (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-11-14
- DOI
- https://doi.org/10.4239/wjd.v16.i11.111223
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52