Impact of achieving glycated hemoglobin targets on cardiovascular events/mortality: <i>Post-hoc</i> analysis of the nephropathy in diabetes type 2 trial
In high-risk patients with T2D receiving standard care, achieving an HbA1c ≤ 7% was associated with fewer cardiovascular events only under standard care, but not with reduced mortality. This association was not observed in patients managed with a multifactorial strategy. These findings suggest that the prognostic value of glycemic control depends on the broader treatment context and highlight the central role of comprehensive risk factor management in microvascular-complicated T2D.
Authors
- Vincenzo Russo (ORCID: https://orcid.org/0000-0002-9227-0360)
- Luca Rinaldi (ORCID: https://orcid.org/0000-0002-6541-3821)
- Roberto Minutolo (ORCID: https://orcid.org/0000-0001-5686-2089)
- Raffaele Galiero (ORCID: https://orcid.org/0000-0002-7766-3430)
- Raffaele Marfella (ORCID: https://orcid.org/0000-0003-3960-9270)
- Alfredo Caturano (ORCID: https://orcid.org/0000-0001-7761-7533)
- Teresa Salvatore (ORCID: https://orcid.org/0000-0002-6532-7122)
- Vittorio Simeon (ORCID: https://orcid.org/0000-0003-2387-4125)
- Paolo Chiodini (ORCID: https://orcid.org/0000-0003-0139-2264)
- Erica Vetrano
- Ferdinando Carlo Sasso (ORCID: https://orcid.org/0000-0002-9142-7848)
- Carlo Acierno (ORCID: https://orcid.org/0000-0002-1239-7012)
- Caterina Conte (ORCID: https://orcid.org/0000-0001-7066-5292)
- Celestino Sardu (ORCID: https://orcid.org/0000-0001-5099-3790)
- Luca De Nicola
Institutions
- San Raffaele University of Rome (IT)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-11-14
- DOI
- https://doi.org/10.4239/wjd.v16.i11.111698
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00