Identifying urosepsis risk in diabetic patients with renal and ureteral calculi: Key predictors and clinical implications

In their retrospective study of 298 diabetic patients with renal/ureteral calculi, Zhou <i>et al</i> identified critical predictors for urosepsis using multivariate logistic regression. Key findings revealed female gender (OR = 2.237, <i>P</i> = 0.03), advanced age (OR = 1.05/year, <i>P</i> = 0.002), fever (OR = 2.999, <i>P</i> = 0.015), severe hydronephrosis (OR = 6.129, <i>P</i> = 0.011), and elevated urinary markers-particularly urine leukocytes (U-LEU+++: OR = 66.0, <i>P</i> < 0.001) and glucose (U-GLU+++: OR = 7.248, <i>P</i> = 0.005) as independent risk factors. These readily accessible clinical parameters offer significant potential for early risk stratification in high-risk populations. While this STROBE-adherent study provides actionable insights, limitations include its single-center design and unaddressed antibiotic protocols. Future multicenter validation should assess residual stone impacts and optimize intervention thresholds. This work establishes a foundation for targeted surveillance protocols in diabetic urolithiasis management.