Mechanism of miR-20b-5p targeting HIF-1α in regulating trophoblast function in recurrent spontaneous abortion
miR-20b-5p negatively regulates trophoblast function by targeting HIF-1α, contributing to trophoblast dysfunction and RSA pathogenesis. The miR-20b-5p/HIF-1α axis may serve as a potential therapeutic target for RSA.
Authors
- Qin Wu (ORCID: https://orcid.org/0000-0003-4371-4372)
- Aizhen Fu
- Yanyu Lai
- Lujing Chen (ORCID: https://orcid.org/0009-0003-1614-966X)
- Yihong Guo (ORCID: https://orcid.org/0009-0008-2918-1147)
Institutions
- Guangdong Medical College (CN)
- Dongguan People’s Hospital (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
- Tang Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s40001-025-03308-6
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province