[99mTc]Tc-PSMA-HSG for PSMA-targeted Hybrid Surgical Guidance: a new addition to the PSMA-I&S/I&T family

The hybrid tracer [<sup>99m</sup>Tc]Tc-PSMA-HSG demonstrates high specificity and favorable pharmacokinetics. Its successful first-in-human application highlights its translational potential for precise intraoperative detection of PSMA-positive lymph node metastases.

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Institutions

Publication Details

Journal
European Journal of Nuclear Medicine and Molecular Imaging
Published
2025-11-14
DOI
https://doi.org/10.1007/s00259-025-07623-2
Citations
1
Primary Topic
Radiopharmaceutical Chemistry and Applications
Type
article
Field-Weighted Citation Impact
1.36

Funders

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article

[99mTc]Tc-PSMA-HSG for PSMA-targeted Hybrid Surgical Guidance: a new addition to the PSMA-I&S/I&T family

Fijs W. B. van Leeuwen, H. W. Koch, Julia Brosch-Lenz, Alexander Gäble et al.
1 citations
European Journal of Nuclear Medicine and Molecular Imaging
Radiopharmaceutical Chemistry and Applications
1.36
article

[99mTc]Tc-PSMA-HSG for PSMA-targeted Hybrid Surgical Guidance: a new addition to the PSMA-I&S/I&T family

Fijs W. B. van Leeuwen, H. W. Koch, Julia Brosch-Lenz, Alexander Gäble, Bruno Märkl, Sebastian Martin, David Viertl, Nic G. Reitsam, Alexandra Litvinenko, Dorothea Weckermann, Margret Schottelius, Marianne Patt, Alessandro Liebich, Johanna S. Enke, Danny M. van Willigen, Tessa Buckle, Constantin Lapa, Hans‐Jürgen Wester
article en
1 citations

Abstract

The hybrid tracer [<sup>99m</sup>Tc]Tc-PSMA-HSG demonstrates high specificity and favorable pharmacokinetics. Its successful first-in-human application highlights its translational potential for precise intraoperative detection of PSMA-positive lymph node metastases.

European Journal of Nuclear Medicine and Molecular ImagingVol. 53(5)
University of Augsburg (DE), Leiden University Medical Center (NL), University Hospital Augsburg (DE), Centre Hospitalier Universitaire Vaudois (CH), Parents' Place of Maryland (US), Swiss Cancer Center Léman (CH), Technical University of Munich (DE)
Ludwig Institute for Cancer Research, Université de Lausanne, Centre Hospitalier Universitaire Vaudois
Openalex Percentile: Top 14%
Radiopharmaceutical Chemistry and Applications
1.36
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