Wallerian degeneration of the corticospinal tract following multimodal high-grade glioma treatment: a case series and recommendations for radiotherapy planning
This retrospective series highlights WDCT as a potentially underrecognized complication in glioma patients undergoing multimodal treatment. While etiology is likely multifactorial, radiotherapy may play a contributing role. CST delineation, when tractography is available, may support individualized treatment planning, enable better assessment of dose exposure, and help identify patients at higher risk of motor decline. Further prospective studies are warranted to define dose thresholds and assess functional outcomes.
Authors
- Mònica Santos (ORCID: https://orcid.org/0000-0003-3229-8270)
- Natasha Maranhão Vieira Rodrigues (ORCID: https://orcid.org/0000-0002-1853-9915)
- Gustavo A. Nader (ORCID: https://orcid.org/0000-0002-2220-4296)
- Fábio Ynoe de Moraes (ORCID: https://orcid.org/0000-0003-3407-9215)
- Samir Abdallah Hanna (ORCID: https://orcid.org/0000-0002-1976-0662)
- Anselmo Mancini
- Julia Brunelli
- Ana Carolina Pinheiro Campos (ORCID: https://orcid.org/0000-0003-2901-5823)
- Caroline Chung
- Olavo Feher (ORCID: https://orcid.org/0000-0001-7812-6576)
- Marcos Vinícius Calfat Maldaun (ORCID: https://orcid.org/0000-0003-0463-2235)
- Franceliny Gibram
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Queen's University (CA)
- Universidade do Vale do Sapucaí (BR)
- Hospital Sírio-Libanês (BR)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fonc.2025.1605190
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00