Diagnostic accuracy of the Cepheid MTB host response assay for the detection of pulmonary TB
The Xpert HR TB assay demonstrated promising sensitivity, but its specificity did not meet minimum target product profiles for a TB triage or case detection test. In its current form, Xpert HR cannot replace more sensitive nucleic acid amplification tests in sputum-productive individuals.
Authors
- Hod Lipson (ORCID: https://orcid.org/0000-0003-0769-4618)
- Wentzel Dowling (ORCID: https://orcid.org/0000-0001-7032-5853)
- Derek T. Armstrong (ORCID: https://orcid.org/0000-0001-6223-4839)
- Yasha Rani (ORCID: https://orcid.org/0000-0003-4254-4383)
- Elizabeth Nakabugo
- Helen Cox (ORCID: https://orcid.org/0000-0002-6538-7192)
- Margaretha de Vos (ORCID: https://orcid.org/0000-0003-3059-2986)
- A Nicholson
- Carlos Zamudio (ORCID: https://orcid.org/0000-0001-7479-127X)
- Yosra Alkabab (ORCID: https://orcid.org/0000-0002-7743-9172)
- Tatiana Cáceres (ORCID: https://orcid.org/0000-0003-0516-5202)
- Lydia Nakiyingi (ORCID: https://orcid.org/0000-0001-7263-3198)
- S. Kim
- Nguyễn Văn Hùng (ORCID: https://orcid.org/0000-0002-7184-0715)
- Mohammed Farhad
- Susan E. Dorman (ORCID: https://orcid.org/0000-0001-6882-9470)
- April Borkman
- C. Hoang
- H. Jinna
Institutions
- Rutgers, The State University of New Jersey (US)
- FIND (CH)
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- University of Cape Town (ZA)
- Universidad Peruana Cayetano Heredia (PE)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Hanoi Lung Hospital (VN)
- Rutgers New Jersey Medical School (US)
- Makerere University (UG)
Publication Details
- Journal
- IJTLD OPEN
- Published
- 2025-11-01
- DOI
- https://doi.org/10.5588/ijtldopen.25.0380
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00