Integrated multi-omics analysis reveals key hub genes and mechanisms in calcific aortic stenosis
The 16 hub genes can assist in the diagnosis of aortic stenosis, and MMP9 and PLAU may participate in AS development by regulating the proinflammatory effects of monocytes and macrophages.
Authors
- Qi Cheng (ORCID: https://orcid.org/0000-0002-2356-4998)
- Jun Cui (ORCID: https://orcid.org/0000-0002-9072-3071)
- Fengxia Wang (ORCID: https://orcid.org/0000-0003-3478-8863)
- Mingjun Duan (ORCID: https://orcid.org/0000-0001-9511-6812)
- Shuai Liu (ORCID: https://orcid.org/0000-0001-8732-9754)
- Fen Liu
- Jie Yu (ORCID: https://orcid.org/0000-0003-3806-2015)
- Xiang Xie (ORCID: https://orcid.org/0000-0002-5555-8488)
- Haijiang Guo
- Yi-tong Ma
- Nilupaer Aisikeer
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fcvm.2025.1640014
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00