Investigating the molecular mechanisms of resveratrol in treating diabetic foot ulcers: a comprehensive analysis of network pharmacology and experiment validation
Overall, this study identified RDGs as a key therapeutic target for resveratrol acting on DFU through a series of bioinformatics analyses and machine learning algorithms. Which not only fills the gap in the molecular mechanism of resveratrol treatment for DFU but also provides a novel therapeutic target for DFU.
Authors
- Daning Liang
- Zhonghua Sun
- Chao Sima
- Zhen‐Ning Zhang (ORCID: https://orcid.org/0000-0003-3798-7104)
- Jianchi Li
- Haiyang Wang (ORCID: https://orcid.org/0000-0002-1302-5747)
- Hongwei Wang (ORCID: https://orcid.org/0000-0002-2902-591X)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-1032-2743)
- Sisi Wang (ORCID: https://orcid.org/0000-0002-0194-8595)
Institutions
- Guangxi Medical University (CN)
- ShenZhen People’s Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fmolb.2025.1708426
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22