Development and evaluation of the phenotypic 2G test to detect drug-resistant TB
In the clinical setting, the 2G test showed a low sensitivity versus Xpert and MGIT. The 2G test sensitivity was lower when frozen instead of fresh sputa was used. Despite these results, important information was collected to further improve this 2G test prototype and its implementation in resource-constrained settings.
Authors
- Belén Saavedra (ORCID: https://orcid.org/0000-0002-4057-0214)
- Gustavo Tembe (ORCID: https://orcid.org/0000-0001-7241-0381)
- S.-H. Wang
- Jonathan Gelfond (ORCID: https://orcid.org/0000-0002-0773-3683)
- Jordi Bertran Torrelles (ORCID: https://orcid.org/0000-0001-7702-5941)
- Edson Mambuque (ORCID: https://orcid.org/0000-0002-9106-1444)
- Shilzia Munguambe (ORCID: https://orcid.org/0000-0002-5433-727X)
- Joshua Garcia (ORCID: https://orcid.org/0000-0002-1696-8783)
- Joan-Miquel Balada-Llasat
- Blanca I. Restrepo (ORCID: https://orcid.org/0000-0002-3743-9098)
- Amberlee Hicks
- Alberto L. García‐Basteiro (ORCID: https://orcid.org/0000-0002-2038-5505)
- Marcel Yotebieng (ORCID: https://orcid.org/0000-0003-2110-2631)
- Alyssa Schami (ORCID: https://orcid.org/0000-0002-5311-7216)
- Natalia Gómez (ORCID: https://orcid.org/0000-0002-4246-9304)
Institutions
- Texas Biomedical Research Institute (US)
- Albert Einstein College of Medicine (US)
- The University of Texas at San Antonio Health Science Center (US)
- The University of Texas Rio Grande Valley (US)
- Centro de Investigación Biomédica en Red (ES)
- Manhiça Health Research Centre (MZ)
- Biomedical Research Institute (US)
- Barcelona Institute for Global Health (ES)
- International Biomedical (United States) (US)
- The Ohio State University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- IJTLD OPEN
- Published
- 2025-11-01
- DOI
- https://doi.org/10.5588/ijtldopen.25.0326
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00