CD302 regulates the malignant phenotypes of lung adenocarcinoma as a tumor suppressor gene
CD302 is expressed at low levels in lung adenocarcinoma tissues, and its expression is negatively correlated with tumor diameter, serving as an independent risk factor for poor prognosis in lung adenocarcinoma patients. Overexpression of CD302 inhibits the proliferation, migration, and invasion of A549 and PC-9 cells. Therefore, CD302 holds potential as a diagnostic and prognostic biomarker for LUAD patients.
Authors
- Xixian Ke (ORCID: https://orcid.org/0000-0002-3242-3257)
- Yao Wang (ORCID: https://orcid.org/0000-0002-9352-422X)
- Kai Wang (ORCID: https://orcid.org/0000-0001-5814-817X)
- Tao Lu (ORCID: https://orcid.org/0000-0002-0013-4987)
- Yongxiang Song (ORCID: https://orcid.org/0000-0003-1022-0202)
- Cheng Chen (ORCID: https://orcid.org/0000-0002-0223-1051)
- Manjun Gao
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fonc.2025.1601706
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00