CD8+ T cells mediate the impact of gut dysbiosis and short-chain fatty acid deficiency on accelerated arthritis progression in collagen-induced arthritis mice
The reduction of SCFAs synthesis caused by gut microbiota dysregulation in CIA mice is related to the expansion of intestinal CD8<sup>+</sup> T cells and may further promote the imbalance of T/B cells in the spleen; this gut microbiota -SCFA- CD8<sup>+</sup> T cell axis may be involved in the occurrence and development of arthritis.
Authors
- Chunxue Fan
- Wenpeng Zhao
- Jian-Fang Xie (ORCID: https://orcid.org/0000-0003-3704-5993)
- Lili Shang
- Xiangcong Zhao
- Yuhang Song
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1702792
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00