Inflammatory and redox reprogramming of macrophages by HIV cell-to-cell transmission inhibits bone resorption capacity
The effects scaled with the proportion of infected T cells. HIV cell-to-cell spread induces inflammatory and redox reprogramming in macrophage precursors that blocks osteoclast differentiation and function, offering testable targets (inflammasome, adhesion, ROS) to protect bone in HIV.
Authors
- Cinthya Alicia Marcela López (ORCID: https://orcid.org/0000-0003-1603-9156)
- Franco Agustín Sviercz
- M. Victoria Delpino (ORCID: https://orcid.org/0000-0003-2077-8509)
- Constanza Russo
- Patricio Jarmoluk
- Nicole Freiberger
- Cintia Cevallos (ORCID: https://orcid.org/0000-0002-9268-0853)
- Jorge Quarleri
Institutions
- Instituto de Investigaciones Biomédicas en Retrovirus y Sida (AR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1694065
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Florencio Fiorini
- Universidad de Buenos Aires
- Agencia Nacional de Promoción Científica y Tecnológica
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires
- Fondo para la Investigación Científica y Tecnológica