Causes and risk factors for death in infants with congenital chylothorax
Poor prognosis in infants with CC is strongly associated with fetal ascites, which we hypothesize serves as a key clinical marker for underlying Generalized Lymphatic Dysplasia (GLD). This systemic lymphatic disorder, identified pathologically as lymphangiectasia in fatal cases, may be the primary driver of mortality. Chromosomal abnormalities appear to be a significant predisposing factor for this severe phenotype.
Authors
- Masato Kamitomo (ORCID: https://orcid.org/0000-0002-4078-8539)
- Yuichi Kubo (ORCID: https://orcid.org/0000-0001-7454-4164)
- Masaya Kibe (ORCID: https://orcid.org/0000-0002-5588-083X)
- Kazuyoshi Sueyoshi
- Motoi Kato (ORCID: https://orcid.org/0000-0002-2996-7771)
- Takuya Tokuhisa (ORCID: https://orcid.org/0000-0001-8580-5657)
- Satoshi Ibara
Institutions
- Shonan Institute of Technology (JP)
- Kagoshima University Hospital (JP)
- Kagoshima City Hospital (JP)
- Imakiire General Hospital (JP)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fped.2025.1699515
- Primary Topic
- Lymphatic Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00