Isoliquiritigenin Attenuates Staphylococcus aureus Adhesion and Invasion to Counteract Staphylococcus aureus Pathogenicity and Infection
ISL effectively attenuates MRSA pathogenicity by targeting SrtA-mediated virulence rather than bacterial viability. These results highlight ISL as a promising antivirulence agent and a potential adjuvant for combating antibiotic-resistant S. aureus infections.
Authors
- Jian Zheng (ORCID: https://orcid.org/0000-0002-6462-3608)
- Libo Zhang (ORCID: https://orcid.org/0000-0002-2972-5174)
- Hongjun Wang (ORCID: https://orcid.org/0000-0003-0954-9385)
- Hong Jiang (ORCID: https://orcid.org/0000-0003-2550-8401)
- Dacheng Wang
- Lili Tian (ORCID: https://orcid.org/0000-0003-0556-4449)
- Jian Sun (ORCID: https://orcid.org/0009-0002-5679-3823)
Institutions
- Jilin University (CN)
- Liaoning University of Technology (CN)
- Beijing Health Vocational College (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1686699
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00