Human spinal enthesis comparative biology of IL-17F and IL-17A reveals greater T-cell IL-17F induction and IL-23 regulation
There was differential induction of IL-17A and IL-17F from innate and adaptive entheseal T cells, with further significant IL-17F augmentation by IL-23, but not IL-17A. Furthermore, the synergistic effects of IL-17A or IL-17F and TNF on stromal function provide the basis for further enthesis IL-17F biology interrogation.
Authors
- Almas Khan (ORCID: https://orcid.org/0000-0002-7916-6219)
- Peter Loughenbury (ORCID: https://orcid.org/0000-0002-0208-2623)
- Avneet Manghera
- Ala Altaie (ORCID: https://orcid.org/0000-0002-9203-1490)
- Stevan Shaw (ORCID: https://orcid.org/0000-0003-3038-2794)
- Dennis McGonagle (ORCID: https://orcid.org/0000-0001-7715-8226)
- Tom Macleod (ORCID: https://orcid.org/0000-0002-7903-2990)
- Vishal Borse
- Charlie Bridgewood (ORCID: https://orcid.org/0000-0001-6797-4633)
- Robert Dunsmuir (ORCID: https://orcid.org/0000-0002-1547-5055)
- N. McDermott
- Abhay Rao
Institutions
- Leeds Teaching Hospitals NHS Trust (GB)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- UCB Pharma (United Kingdom) (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1658325
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Leeds Biomedical Research Centre
- UCB Pharma