Factors influencing preterm infant microbiota and their role in wheezing development
The microbiota of preterm neonates during the first week of life plays a pivotal role in determining the risk of respiratory diseases, such as wheezing, later in life. Clinical factors such as antibiotic use, delivery mode, and breastfeeding have a profound impact on microbiota composition, with specific genera such as Moraxella, Corynebacterium, and Bifidobacterium emerging as key biomarkers, making them important targets for interventions to promote long-term respiratory health in preterm infants. To recognize microbial predictors of recurrent wheezing in preterm infants could allow to explore potential microbiota-modulating strategies to mitigate respiratory complications in this high-risk population.
Authors
- Jorge Atucha
- Raúl Cabrera‐Rubio (ORCID: https://orcid.org/0000-0003-3652-9558)
- Inmaculada Casas (ORCID: https://orcid.org/0000-0003-1840-1198)
- Patricia Alonso (ORCID: https://orcid.org/0009-0003-2940-579X)
- Cristina Calvo (ORCID: https://orcid.org/0000-0002-6503-3423)
- Sergio Quevedo (ORCID: https://orcid.org/0000-0002-5915-5192)
- María Carmen Collado (ORCID: https://orcid.org/0000-0002-6204-4864)
- María Luz García‐García (ORCID: https://orcid.org/0000-0003-4906-4227)
- Francisco Pozo (ORCID: https://orcid.org/0000-0003-1828-733X)
- Sonia Alcolea (ORCID: https://orcid.org/0000-0003-1233-1723)
- María Arroyas (ORCID: https://orcid.org/0000-0002-8717-0322)
- Laura Sánchez‐García (ORCID: https://orcid.org/0000-0002-8420-1701)
- Leticia Labanda
Institutions
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Instituto de Agroquímica y Tecnología de Alimentos (ES)
- Spanish Clinical Research Network (ES)
- Centro de Investigación Biomédica en Red (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Research Network (United States) (US)
- Hospital Universitario Severo Ochoa (ES)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1038/s41390-025-04569-x
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Generalitat Valenciana
- Ministerio de Ciencia e Innovación
- Agencia Estatal de Investigación