S100A4 Induces Neutrophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps via TLR4 Pathway
S100A4 is elevated in neutrophilic CRSwNP and exerts its pro-inflammatory effect on nasal epithelial cells via TLR4 signaling cascade.
Authors
- Chunhao Li (ORCID: https://orcid.org/0000-0002-1872-4870)
- Yanyi Tu (ORCID: https://orcid.org/0000-0001-5729-5231)
- Aiping Chen
- Shengyang Liu
- De Yun Wang (ORCID: https://orcid.org/0000-0002-0909-2963)
- Yuzhu Wan (ORCID: https://orcid.org/0000-0001-6184-5902)
- Ping Li (ORCID: https://orcid.org/0000-0003-0958-6784)
- Linghui Meng (ORCID: https://orcid.org/0000-0002-2683-8069)
- Tao Li (ORCID: https://orcid.org/0000-0002-9637-778X)
- Shi Li
- Jing Liu (ORCID: https://orcid.org/0000-0002-9377-1626)
Institutions
- National University of Singapore (SG)
- Peking Union Medical College Hospital (CN)
- Shandong Provincial Hospital (CN)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1007/s10875-025-01953-4
- Citations
- 2
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province