The Impact of Early Belimumab Use on Successful Glucocorticoid Tapering to a Low Maintenance Dose in Treatment‐naïve, Newly Diagnosed Systemic Lupus Erythematosus
Early belimumab initiation was associated with glucocorticoid tapering and higher LLDAS attainment in treatment-naïve SLE patients, potentially reducing long-term steroid-related risks. High-dose glucocorticoid induction therapy and rapid tapering approaches appear safe without increasing cumulative glucocorticoid exposure, supporting their consideration in clinical practice.
Authors
- Yukihiko Ikeda
- Masato Okada
- Takehiro Nakai (ORCID: https://orcid.org/0000-0003-0588-9518)
- Mitsumasa Kishimoto (ORCID: https://orcid.org/0000-0002-4007-1589)
- Masei Suda (ORCID: https://orcid.org/0000-0002-2036-6216)
- Sho Fukui (ORCID: https://orcid.org/0000-0002-3082-1374)
- Hiromichi Tamaki (ORCID: https://orcid.org/0009-0009-9620-9995)
Institutions
- Brigham and Women's Hospital (US)
- Kyorin University (JP)
- St. Luke's International Hospital (JP)
- Suwa Red Cross Hospital (JP)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1111/1756-185x.70462
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00