Chiral Borane-Catalyzed Asymmetric Hydrosilylation of 2,3,3-Trisubstituted 3 <i>H</i> -Indoles
An asymmetric Piers-type hydrosilylation of 2,3,3-trisubstituted 3<i>H</i>-indoles has been achieved for the first time using a chiral borane catalyst derived by the in situ hydroboration of a chiral monoalkene with HB(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub>. A broad range of optically active indolines were afforded in moderate to high yields with 60-95% ee.
Authors
- Xiangqing Feng (ORCID: https://orcid.org/0000-0003-1739-925X)
- Fuqu Zou
- Haifeng Du (ORCID: https://orcid.org/0000-0003-0122-3735)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Institute of Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1021/acs.joc.5c02315
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00