Meta-Analysis of the Efficacy of Platelet-Rich Plasma in Treating Skin Aging

Abstract Background Platelet-rich plasma (PRP), enriched with growth factors, shows promise in skin rejuvenation, yet lacks robust evidence. Objectives This meta-analysis aims to evaluate the clinical efficacy of platelet-rich plasma (PRP) in the treatment of skin aging. Methods Relevant randomized controlled trials (RCTs) published up to December 1, 2024, were identified by searching PubMed, Embase, CNKI, Wanfang Database, VIP and Cochrane Library. Data extraction and quality assessment were conducted independently by two researchers. RevMan 5.4 and STATA software were used to calculate overall effect sizes with 95% confidence intervals (CIs), and risk of bias was assessed. Results A total of 9 RCTs involving 358 patients were included. The meta-analysis showed that PRP interventions significantly improved subjective patient satisfaction, with a risk ratio (RR) of 1.34 (95% CI: 1.07-1.67, P = .01). PRP also demonstrated significant advantages over the control group in terms of objective efficacy, with an RR of 1.42 (95% CI: 1.01-2.00, P = .04). Differences between the PRP and control groups were statistically significant (P < .05). Although some studies reported that PRP might increase adverse effects, pooled analysis showed no significant difference between the two groups (RR = 1.21, 95% CI: 0.50-2.92, P = .67). Conclusions PRP, as a minimally invasive and low-risk treatment, has demonstrated efficacy in alleviating skin aging and improving skin texture. It shows promising clinical application potential. Level of Evidence: 2 (Therapeutic)