Targeting the Galectin Axis in Osteoarthritis: Chondroprotective Effects of Dietary and Pharmacological Phytochemicals
Our study identifies Brazilin, Diacerein, and Resveratrol as promising modulators of galectin-driven cartilage degeneration and demonstrates the translational potential of patient-derived chondrogenic pellets as a human-relevant platform for preclinical drug evaluation in OA. The 3D culture effectively recapitulates key aspects of OA pathophysiology and offers a robust system to advance therapeutic discovery targeting ECM remodeling.
Authors
- Reinhard Windhager (ORCID: https://orcid.org/0000-0002-6321-1804)
- Mario Rothbauer (ORCID: https://orcid.org/0000-0002-9928-3631)
- Herbert Kaltner (ORCID: https://orcid.org/0000-0003-4680-8411)
- Katharina M. Pichler (ORCID: https://orcid.org/0000-0001-9944-9999)
- Jürgen Alphonsus (ORCID: https://orcid.org/0000-0002-4444-0134)
- Sebastian Schmidt (ORCID: https://orcid.org/0009-0006-6700-0437)
- Stefan Toegel (ORCID: https://orcid.org/0000-0003-4317-1769)
- Selina Kottinger (ORCID: https://orcid.org/0009-0001-3423-7001)
- Bettina Rodriguez Molina (ORCID: https://orcid.org/0009-0007-5329-3010)
Institutions
- TU Wien (AT)
- Ludwig Boltzmann Institute for Digital Health and Prevention (AT)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Molecules
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3390/molecules30224391
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00