Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025
We measured effectiveness of nirsevimab against laboratory-confirmed respiratory syncytial virus (RSV) infection in a test-negative case-control study among children aged < 24 months hospitalised for severe acute respiratory infection in three European countries. The overall effectiveness in the 2024/25 season among 2,201 children was 79% (95% CI: 58 to 89) and 85%, 78% and 69% at < 30, 30-89 and 90-215 days since immunisation. Immunisation was effective for preventing RSV-related hospitalisation in children, but effectiveness by time since immunisation needs monitoring in future seasons.
Authors
- Marie-Laure Parsy
- Iris Ganser (ORCID: https://orcid.org/0000-0002-1895-1248)
- Adrien Lajot (ORCID: https://orcid.org/0000-0001-9614-2641)
- Mathil Vandromme (ORCID: https://orcid.org/0000-0001-6033-246X)
- Camelia Savulescu (ORCID: https://orcid.org/0000-0002-5374-835X)
- Sabrina Bacci (ORCID: https://orcid.org/0000-0002-6575-3439)
- Nathalie Nicolay (ORCID: https://orcid.org/0000-0002-5916-7855)
- Sthefany Pereira Campos
- Angela MC Rose (ORCID: https://orcid.org/0000-0002-2493-8082)
- A. Arévalo Garrido
- Vânia Gaio (ORCID: https://orcid.org/0000-0001-7626-4991)
- Iván Martínez‐Baz (ORCID: https://orcid.org/0000-0002-3405-2277)
- Ana Paula Rodrigues
- Raquel Guiomar
- Aitziber Echeverría (ORCID: https://orcid.org/0009-0002-2822-819X)
- Marta Cara-Rodríguez
Institutions
- Universidad Nacional de Educación a Distancia (ES)
- Instituto de Salud Carlos III (ES)
- Instituto de Salud Pública de Navarra (ES)
- Centre Hospitalier de Wallonie Picarde (BE)
- National Institute of Health Dr. Ricardo Jorge (PT)
- Sciensano (Belgium) (BE)
- Consejería de Salud y Consumo (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Complejo Hospitalario de Cáceres (ES)
- European Centre for Disease Prevention and Control (SE)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2025-11-13
- DOI
- https://doi.org/10.2807/1560-7917.es.2025.30.45.2500816
- Citations
- 1
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 1.35