Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice
These findings demonstrate that ketamine induces dynamic alterations in brain glucose metabolism accompanied by molecular adaptations. The early hypermetabolic response may reflect acute excitatory effects, whereas longer exposure could engage compensatory or stress-associated mechanisms. Metabolic imaging may provide a useful, non-invasive approach to better understand ketamine's temporal effects and support long-term safety monitoring.
Authors
- Eosu Kim (ORCID: https://orcid.org/0000-0001-9472-9465)
- Sun Min Lim (ORCID: https://orcid.org/0000-0001-7694-1593)
- Ho‐Taek Song (ORCID: https://orcid.org/0000-0002-6655-2575)
- Young‐Suk Choi (ORCID: https://orcid.org/0000-0003-4930-8455)
- Chul Hoon Kim (ORCID: https://orcid.org/0000-0002-7360-429X)
Institutions
- Yonsei University (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fphar.2025.1629824
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea