Genetic polymorphisms in the E2 glycoprotein of chikungunya virus (2014-2023) and their potential implications for immunity and vaccine design
These findings indicate that a relevant number of mutations have accumulated in CHIKV circulating in Brazil and worldwide, with potential to impact immunological control of the virus and its replication and pathogenesis.
Authors
- Ruth Dálety da Silva Brito
- Eric Roberto Guimarães Rocha Aguiar (ORCID: https://orcid.org/0000-0002-8143-5756)
- Patrı́cia Antunes (ORCID: https://orcid.org/0000-0002-3553-2678)
- Wilson Barros Luiz (ORCID: https://orcid.org/0000-0003-3265-8547)
- Mayanna Moreira Costa Fogaça
- Milena Silva Souza (ORCID: https://orcid.org/0000-0002-2556-9178)
- Alexander Birbrair (ORCID: https://orcid.org/0000-0003-1015-2561)
- Jaime Henrique Amorim (ORCID: https://orcid.org/0000-0002-0623-2879)
- Ricardo Durães-Carvalho
- Paloma Oliveira Vidal
Institutions
- University of Wisconsin–Madison (US)
- Universidade Federal do Oeste da Bahia (BR)
- Universidade Estadual de Santa Cruz (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1016/j.ijid.2025.108193
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00