Distinct Roles of Cerebellar Afferent and Efferent Fiber Tracts in Craniocervical Dystonia
Our study revealed a functional segregation of cerebellar pathways in CCD: the efferent pathways were linked to disease pathogenesis, whereas the afferent pathways were associated with STN-DBS outcomes. This study will foster a better understanding of the pathophysiological mechanisms of CCD and facilitate the development of optimized DBS strategies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Zhiqi Mao (ORCID: https://orcid.org/0000-0002-8535-4531)
- Xiaoyu Xu (ORCID: https://orcid.org/0000-0003-1236-1957)
- Jun‐Peng Xu (ORCID: https://orcid.org/0000-0001-6077-8074)
- Yanyang Zhang (ORCID: https://orcid.org/0000-0003-2162-7358)
- Jun Yang (ORCID: https://orcid.org/0000-0001-9816-8108)
- Zaixu Cui (ORCID: https://orcid.org/0000-0003-4385-8106)
- Jingyu Feng (ORCID: https://orcid.org/0000-0002-4236-4318)
- Bin Liu (ORCID: https://orcid.org/0000-0003-1569-2604)
- Wenjie Li (ORCID: https://orcid.org/0009-0008-6119-487X)
- Xin Chen (ORCID: https://orcid.org/0000-0001-7720-8916)
- Tao Yu (ORCID: https://orcid.org/0009-0003-5701-9642)
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Chinese Institute for Brain Research (CN)
- Peking University Third Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/mds.70118
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Young Scientists Fund