Polygenic Vulnerability to Intracranial Hypertension, Hemorrhage Progression, and Outcome in Traumatic Brain Injury
Polygenic variability in key nodes linked to SUR1-TRPM4 were associated with mechanistically related secondary injuries and outcome after severe TBI; findings suggest a major role of heritability. Functional implications indicate biological plausibility and identify novel targets. The data, whereas requiring validation, support a shift toward incorporating biologically relevant genetics in advancing precision medicine. ANN NEUROL 2026;99:459-477.
Authors
- Joshua S. Catapano (ORCID: https://orcid.org/0000-0001-6599-0269)
- Matthew Pease (ORCID: https://orcid.org/0000-0001-6125-9858)
- David O. Okonkwo (ORCID: https://orcid.org/0000-0002-7444-2851)
- Yvette P. Conley (ORCID: https://orcid.org/0000-0002-1784-6067)
- Charles S. Cox (ORCID: https://orcid.org/0000-0002-9155-3676)
- Margaux Miller
- Aditya Kumar (ORCID: https://orcid.org/0000-0002-6474-8830)
- Ruchira Menka Jha (ORCID: https://orcid.org/0000-0002-3047-7649)
- Ava M. Puccio (ORCID: https://orcid.org/0000-0003-2569-9607)
- Chia‐Ling Phuah (ORCID: https://orcid.org/0000-0002-6705-7621)
- Adam T. Eberle (ORCID: https://orcid.org/0009-0003-3905-7338)
- Benjamin E. Zusman (ORCID: https://orcid.org/0000-0003-2887-8934)
- Patrick M. Kochanek (ORCID: https://orcid.org/0000-0002-2627-913X)
- Elizabeth M. McNally (ORCID: https://orcid.org/0000-0002-1221-719X)
- Shashvat M. Desai (ORCID: https://orcid.org/0000-0001-9013-6929)
- Anupama Rani (ORCID: https://orcid.org/0000-0002-3913-4618)
- Semeon Afework
- Raemier Anne M. Javelosa
- Nasathapot Namphol
Institutions
- Brigham and Women's Hospital (US)
- Joint Commission (US)
- Barrow Neurological Institute (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Massachusetts General Hospital (US)
- Indiana University Bloomington (US)
- HonorHealth (US)
- Herman Miller (United States) (US)
- The University of Texas Health Science Center (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/ana.78064
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00