Outcomes of Sequential Immune Checkpoint Inhibitor Retreatment After Atezolizumab Plus Bevacizumab in Patients With Unresectable Hepatocellular Carcinoma
Sequential ICI retreatment may be a viable therapeutic option for selected patients with uHCC, particularly those with a favorable response to prior Atez + Bev. Although less effective than first-line therapy, careful patient selection and monitoring ensure efficacy with acceptable safety.
Authors
- Hideki Kobara (ORCID: https://orcid.org/0000-0002-8508-827X)
- Tomotake Shirono (ORCID: https://orcid.org/0000-0002-2662-6779)
- Yasuto Takeuchi (ORCID: https://orcid.org/0000-0003-3261-0842)
- Takafumi Yamamoto (ORCID: https://orcid.org/0000-0002-9904-1894)
- Norikazu Tanabe (ORCID: https://orcid.org/0009-0005-9502-8886)
- Joji Tani (ORCID: https://orcid.org/0000-0001-8801-2505)
- Yuki Kanayama (ORCID: https://orcid.org/0000-0002-8639-5212)
- Hisamitsu Miyaaki (ORCID: https://orcid.org/0000-0002-8067-4376)
- Takeshi Hatanaka (ORCID: https://orcid.org/0000-0003-3656-285X)
- Tetsuji Takayama (ORCID: https://orcid.org/0000-0002-0175-1573)
- Tetsu Tomonari (ORCID: https://orcid.org/0000-0002-8484-9866)
- Shigeo Shimose (ORCID: https://orcid.org/0000-0003-2068-8386)
- Ryu Sasaki (ORCID: https://orcid.org/0000-0002-0001-7377)
- Kyo Sasaki
- Motoyuki Otsuka (ORCID: https://orcid.org/0000-0003-2869-2881)
- Atsushi Naganuma (ORCID: https://orcid.org/0000-0003-0663-0102)
- Hiroki Kawashima (ORCID: https://orcid.org/0000-0002-3720-781X)
- Issei Saeki (ORCID: https://orcid.org/0000-0001-5885-5042)
- Hideki Iwamoto (ORCID: https://orcid.org/0000-0001-5688-1335)
- Taro Takami (ORCID: https://orcid.org/0000-0002-6689-4989)
- Satoru Kakizaki (ORCID: https://orcid.org/0000-0003-0224-7093)
- Takumi Kawaguchi (ORCID: https://orcid.org/0000-0002-7064-4325)
- Sohji Nishina
- Takanori Ito (ORCID: https://orcid.org/0000-0002-1879-3550)
Institutions
- Kurume University (JP)
- Yamaguchi University (JP)
- Kawasaki Medical School (JP)
- Kagawa University (JP)
- Nagoya University Hospital (JP)
- Okayama University Hospital (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Nagasaki University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/jgh.70150
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Global Health and Medicine
- Japan Society for the Promotion of Science