Gepants for headache prevention in children and adolescents: A multicenter chart review study
In this real-world evidence study, gepants for headache prevention in youth were generally well tolerated. Despite failure of multiple prior therapies, some patients benefited from these treatments. This small study was not designed to directly compare the effectiveness of the two medications. Both safety and efficacy in this population need further evaluation in randomized controlled trials.
Authors
- Hannah Shapiro (ORCID: https://orcid.org/0000-0001-7637-4517)
- Ann Oh (ORCID: https://orcid.org/0009-0005-9388-2026)
- Oyepeju Onifade (ORCID: https://orcid.org/0000-0003-2448-9800)
- Christina L. Szperka (ORCID: https://orcid.org/0000-0003-4786-8889)
- Amy A. Gelfand (ORCID: https://orcid.org/0000-0002-0911-7905)
- Blanca Marquez de Prado (ORCID: https://orcid.org/0009-0005-5350-3853)
- Nichelle Raj
- Jessica Saunders
- Lauren Shin (ORCID: https://orcid.org/0009-0005-0782-092X)
- Olivia Mentz
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Hospital of Philadelphia (US)
- UCSF Benioff Children's Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Headache The Journal of Head and Face Pain
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/head.15087
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Patient-Centered Outcomes Research Institute
- American Headache Society
- National Institutes of Health
- University of California, San Francisco
- National Institute of Child Health and Human Development