Two-Year Follow-Up of Humoral and Cellular Immune Responses to SARS-CoV-2 in Healthcare Professionals
The study demonstrates long-term durability of IgG and neutralizing antibodies and confirms durable cellular immunity up to two years postvaccination. Hybrid immunity significantly enhanced neutralizing antibody levels, supporting its added value in protective immunity against SARS-CoV-2.
Authors
- Alena Kloudová (ORCID: https://orcid.org/0000-0002-2589-4229)
- Eduard Ježo
- Hana Tomášková (ORCID: https://orcid.org/0000-0002-9608-1276)
- Hana Zelená (ORCID: https://orcid.org/0000-0002-9232-7566)
- Jan Martínek (ORCID: https://orcid.org/0000-0001-6869-7391)
- Rastislav Maďar (ORCID: https://orcid.org/0009-0008-7719-310X)
- Silvie Ostřížková (ORCID: https://orcid.org/0009-0005-2557-3512)
- Denisa Budirská
Institutions
- University of Ostrava (CZ)
- Public Health Institute Ostrava (CZ)
Publication Details
- Journal
- Vaccines
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3390/vaccines13111163
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00