Phenotypic profile and molecular mechanism of resistance in carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa isolates from Brazilian hospitals: implications for the introduction of imipenem-relebactam
This study highlights the emergence of significant resistance to imipenem-relebactam in Brazil, driven by both enzymatic and non-enzymatic mechanisms. Ongoing molecular surveillance and tailored treatment strategies are essential to address the evolving threat of multidrug-resistant Gram-negative infections in endemic regions.
Authors
- Bianca Brandão de Paula Antunes (ORCID: https://orcid.org/0000-0003-4220-0185)
- Arthur M. Albuquerque (ORCID: https://orcid.org/0000-0002-4472-6378)
- Bruno Rocha Pribul
- Pedro Fernandez Del Peloso (ORCID: https://orcid.org/0000-0001-9309-0540)
- Fernando A. Bozza (ORCID: https://orcid.org/0000-0003-4878-0256)
- Grazielle Viana Ramos (ORCID: https://orcid.org/0000-0002-7149-5448)
- Pedro Kurtz (ORCID: https://orcid.org/0000-0002-4469-8645)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Pontifícia Universidade Católica do Rio de Janeiro (BR)
- D’Or Institute for Research and Education (BR)
- Instituto Evandro Chagas (BR)
- Instituto Estadual do Cérebro Paulo Niemeyer (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1689777
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00