Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis
Collectively, our systems immunology approach highlights potential associations between Treg dysfunctionality and OA-related pain, providing new hypotheses into the adaptive immune system's contribution to OA-related pain.
Authors
- Caroline Aheng
- Adrien Six (ORCID: https://orcid.org/0000-0001-5898-555X)
- Signe Hässler (ORCID: https://orcid.org/0000-0003-4263-3079)
- Nicolas Tchitchek (ORCID: https://orcid.org/0000-0003-3307-0446)
- Alice Courties
- Roberta Lorenzon (ORCID: https://orcid.org/0009-0008-2405-9388)
- Encarnita Mariotti‐Ferrandiz (ORCID: https://orcid.org/0000-0002-8770-0186)
- Jérémie Sellam (ORCID: https://orcid.org/0000-0002-1814-6003)
- Marie Binvignat (ORCID: https://orcid.org/0000-0001-7473-7636)
- Claire Ribet
- Atul J. Butte (ORCID: https://orcid.org/0000-0002-7433-2740)
- Michèlle Rosenzwajg
- David Klatzmann (ORCID: https://orcid.org/0000-0002-0054-3422)
- Alexandra Roux
- Nicolas Coatnoan (ORCID: https://orcid.org/0000-0003-4129-0019)
- Vanessa Mhanna (ORCID: https://orcid.org/0000-0002-9354-7210)
- María Salvador (ORCID: https://orcid.org/0000-0002-6865-7397)
- Fabien Pitoiset (ORCID: https://orcid.org/0000-0001-9950-4011)
- Paul Stys (ORCID: https://orcid.org/0000-0003-4152-2887)
- Johanna Dubois (ORCID: https://orcid.org/0009-0009-0440-150X)
- Hélène Vantomme (ORCID: https://orcid.org/0009-0008-8759-1208)
- Leslie Adda
- Francis Bérenbaum (ORCID: https://orcid.org/0000-0001-8252-7815)
- Pierre Barennes (ORCID: https://orcid.org/0000-0002-3017-0719)
- Lise Minssen
- Kenz Le Gouge
- Michèle Sastre
Institutions
- Inserm (FR)
- University of California, San Francisco (US)
- Institut Universitaire de France (FR)
- Sorbonne Université (FR)
- Institut thématique Immunologie, inflammation, infectiologie et microbiologie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Immunité et Cancer (FR)
- Bipar (FR)
- Centre de Recherche Saint-Antoine (FR)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/art.43437
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Gilead Sciences
- Les Laboratories Pierre Fabre
- Agence Nationale de la Recherche
- Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
- Servier
- Sorbonne Université
- Chugai Pharmaceutical