Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus
Vorinostat ameliorates the severity of disease in SLE-prone mice by simultaneously suppressing IFN-I production and plasma cell differentiation by targeting HDAC6. Thus, vorinostat is a promising therapeutic agent for SLE and may benefit patients with SLE requiring more effective and better-tolerated therapies.
Authors
- Takayuki Shibahara (ORCID: https://orcid.org/0009-0006-6996-431X)
- Kohei Tsujimoto (ORCID: https://orcid.org/0000-0001-6958-2983)
- Hachiro Konaka
- Takehiro Hirayama (ORCID: https://orcid.org/0000-0002-6345-3985)
- Atsushi Kumanogoh (ORCID: https://orcid.org/0000-0003-4749-7117)
- Masayuki Nishide (ORCID: https://orcid.org/0000-0001-6060-1228)
- Masashi Narazaki (ORCID: https://orcid.org/0000-0002-5613-4409)
- Eri Itotagawa (ORCID: https://orcid.org/0000-0003-0263-1108)
- Ken J. Ishii (ORCID: https://orcid.org/0000-0002-6728-3872)
- Wataru Aoki (ORCID: https://orcid.org/0000-0002-3118-9390)
- Sumiyuki Nishida
- Yoshihito Shima (ORCID: https://orcid.org/0000-0002-2523-2938)
- Hyota Takamatsu (ORCID: https://orcid.org/0000-0002-0382-5142)
- JeongHoon Park (ORCID: https://orcid.org/0000-0003-3784-3231)
- Yasuhiro Kato (ORCID: https://orcid.org/0000-0002-4050-2350)
- Tatsunori Jo (ORCID: https://orcid.org/0000-0001-5435-3723)
- Chiaki Nishizawa
Institutions
- Osaka University of Economics (JP)
- Kyoto University (JP)
- Osaka City University (JP)
- Osaka Police Hospital (JP)
- Osaka Minami Medical Center (JP)
- Osaka International Cancer Institute (JP)
- Osaka Red Cross Hospital (JP)
- Nippon Medical School Hospital (JP)
- Osaka University Hospital (JP)
- Osaka International University (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/art.43434
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Center of Innovation Program