Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
To our knowledge, this work represents the first successful establishment of a conditional knockout model in the golden Syrian hamster, providing a valuable tool for mechanistic studies of gene function and disease modeling.
Authors
- Jiangning Liu (ORCID: https://orcid.org/0000-0002-1264-6664)
- Weining Kong (ORCID: https://orcid.org/0000-0002-6170-5704)
- Xunde Xian (ORCID: https://orcid.org/0000-0003-3059-1254)
- Wei Huang (ORCID: https://orcid.org/0000-0001-9683-7590)
- Shan Gao (ORCID: https://orcid.org/0000-0001-5135-7278)
- Xiaolong Qi (ORCID: https://orcid.org/0000-0001-5084-6731)
- Shuyi Shi (ORCID: https://orcid.org/0009-0001-2265-0114)
- Feifei Guan (ORCID: https://orcid.org/0000-0003-3421-2768)
- Yuanwu Ma (ORCID: https://orcid.org/0000-0002-1882-1777)
- Shuo Pan (ORCID: https://orcid.org/0000-0002-1036-4890)
- Rui Fan (ORCID: https://orcid.org/0000-0001-6757-9422)
- Yuhui Wang (ORCID: https://orcid.org/0000-0003-2936-3377)
- Wei Chen (ORCID: https://orcid.org/0000-0001-5451-6430)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-9784-0481)
- Xia Li (ORCID: https://orcid.org/0000-0001-9286-0718)
- Yu‐Wen Su (ORCID: https://orcid.org/0000-0001-6730-8219)
- Gefan Wan
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Institute of Laboratory Animal Science (CN)
- Tianjin haihe hospital (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/ame2.70107
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking University
- National Key Research and Development Program of China