Preclinical Evaluation of a Pilocarpine–(R)-Lipoic Acid Eye Drop for Presbyopia
The dual-mechanism design of CLX-162 addresses the oxidative stress-driven lens changes underlying presbyopia, bridging preclinical findings to future patient care.
Authors
- Mahesh Kandula
- Korawin Triyasakorn (ORCID: https://orcid.org/0009-0008-4494-7497)
- Edward J. Robb
- Subbu Apparsundaram
- John M. York (ORCID: https://orcid.org/0000-0002-3973-9043)
- Marina L. Mamarian
- Jason Christidhis
- Joshua Buffington
Institutions
- Texas Christian University (US)
- University of California System (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Environmental and Occupational Health Sciences Institute (US)
- Fallbrook Engineering (United States) (US)
- Cellix Bio (India) (IN)
- Cellectar Biosciences (United States) (US)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1167/tvst.14.11.17
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca