Lifelong Evolution of Autoreactive Plasma Cell Numbers, Affinity, and Anatomic Location in Arthritic K/ <scp>BxN</scp> Mice
Our results report the dynamic nature of the autoimmune B cell response in the K/BxN model, revealing a transient phase of antibody affinity maturation early in disease that allows high-affinity antibody responses.
Authors
- Andrew D. Griffiths (ORCID: https://orcid.org/0000-0002-0808-3539)
- Matteo Broketa (ORCID: https://orcid.org/0000-0001-7825-1174)
- Pierre Bruhns (ORCID: https://orcid.org/0000-0002-4709-8936)
- Angga Perima (ORCID: https://orcid.org/0000-0001-5566-0362)
- Carlos Castrillón (ORCID: https://orcid.org/0000-0003-2909-7371)
- Patrick England (ORCID: https://orcid.org/0000-0001-6410-5918)
- Odile Richard (ORCID: https://orcid.org/0000-0002-6263-2375)
- François Huetz (ORCID: https://orcid.org/0000-0001-8704-1881)
- Thibault Vanhoucke
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Sorbonne Nouvelle (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Sorbonne Université (FR)
- Université Paris 1 Panthéon-Sorbonne (FR)
- ESPCI Paris (FR)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/art.43436
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica