DNA methylation-mediated ADA overexpression drives pancreatic cancer progression
This study identifies ADA as a prioritized, genetically supported druggable target for PC, supported by colocalization evidence (PPH4 = 0.7949), and elucidates the regulatory role of DNA methylation at the cg20622019 locus. Notably, other significantly screened genes (e.g., PDE2A) failed colocalization validation.
Authors
- Weijie Xu (ORCID: https://orcid.org/0000-0001-5488-222X)
- Hegen Li
- Jie Zeng
- Juying Jiao (ORCID: https://orcid.org/0000-0003-4435-9931)
- Bo Lin (ORCID: https://orcid.org/0000-0002-5755-240X)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1007/s12672-025-04014-9
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00