Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study
In patients with pcJIA receiving the selected dose from baseline, pharmacokinetic exposure was comparable to a dose of 200 mg q2w for adults with rheumatoid arthritis. Clinically relevant improvements were observed in disease activity, with safety being consistent with the known profile of sarilumab.
Authors
- Zbigniew Żuber (ORCID: https://orcid.org/0000-0001-9581-0601)
- Ivan Foeldvari (ORCID: https://orcid.org/0000-0003-0659-5298)
- Katherine Marzan
- Lydie Baret‐Cormel
- Gabriel Vega‐Cornejo (ORCID: https://orcid.org/0000-0001-7637-2933)
- Raul Barria
- Daniel Clemente (ORCID: https://orcid.org/0000-0002-1605-7488)
- Christine Xu
- Bolanle Akinlade (ORCID: https://orcid.org/0000-0003-2334-5717)
- Fabrizio De Benedetti (ORCID: https://orcid.org/0000-0001-8749-8232)
- Pierre Quartier (ORCID: https://orcid.org/0000-0002-1769-549X)
- Angeliki Giannelou
- Nadina Rubio‐Pérez (ORCID: https://orcid.org/0000-0002-7685-3734)
- Alberto J. Spindler
- Nancy Liu (ORCID: https://orcid.org/0009-0009-8104-733X)
- Irina Nikishina
- Inmaculada Calvo Penadés
- Anna Kozlova
- Fei Cao‐Ghoul
- Stephen DiMartino (ORCID: https://orcid.org/0009-0002-9165-9419)
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Children's Hospital of Los Angeles (US)
- Universidad Autónoma de Nuevo León (MX)
- University of Concepción (CL)
- Regeneron (United States) (US)
- Université Paris Cité (FR)
- New York Times (US)
- Morristown Medical Center (US)
- Sanofi (France) (FR)
- Hospital Universitari i Politècnic La Fe (ES)
- Sorbonne Paris Cité (FR)
- Unidad de Artritis y Reumatismo (MX)
- Schön Klinik Hamburg Eilbek (DE)
- Hospital Infantil Universitario Niño Jesús (ES)
- Association of Rheumatologists of Russia (RU)
- Bambino Gesù Children's Hospital (IT)
- Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology (RU)
- Centro Científico Tecnológico - Tucumán (AR)
- C3I (United States) (US)
- Andrzej Frycz Modrzewski Krakow University (PL)
- University of Bío-Bío (CL)
- Hospital Privado (AR)
Publication Details
- Journal
- Arthritis Care & Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/acr.25692
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Sanofi
- Regeneron Pharmaceuticals