Clinical application of boron neutron capture therapy for cancer treatment: A systematic review

Boron neutron capture therapy (BNCT) combines boron drug delivery and heavy-ion therapy. The key factors in the application of BNCT are high-quality neutron beams and boron-containing compounds. It can be used to treat gliomas, meningiomas, melanomas, and recurrent head and neck cancers. To promote the research and development of accelerator-based neutron sources, increase the tumor targeting capability of boron drugs, and improve BNCT efficacy in treating malignancies, this review provides an overview of the development of boron-containing compounds and the progress made in clinical studies using BNCT.