LINC01063 promotes colon cancer progression via the miR-134-5p/KRAS axis and serves as a prognostic biomarker
In this study, we demonstrated that LINC01063 can be used as an independent prognostic marker for colon cancer and explored its promotion of colon cancer cancer progression through the miR-134-5p/KRAS axis. Future studies will focus on in vivo validation and elucidation of downstream signaling cascades, while clinically, LINC01063 holds potential as a prognostic indicator and a therapeutic target for KRAS-mutant colon cancer, aiding in personalized treatment strategies.
Authors
- Rui Fan (ORCID: https://orcid.org/0000-0001-5308-1455)
- Sijia Sun (ORCID: https://orcid.org/0000-0001-8268-3340)
- Qianli Liu (ORCID: https://orcid.org/0000-0002-7629-5648)
Institutions
- Jiamusi University (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Jingzhou Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1007/s12672-025-03961-7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00